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Finally, glutathione deficiency is known to contribute to oxidative stress, and has an important role in aging, as well as in the pathogenesis of different diseases, such as neurodegenerative diseases, liver and kidney disorders, cystic fibrosis, diabetes, and cardiovascular illness
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Notably, psychosocial isolation, which increases with age (Dahlberg et al., 2024), compounds circadian disruption by weakening social and environmental zeitgebers, activating neuroendocrine stress responses and sleep disturbances (Stafford et al., 2013
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